While perusing DVDBeaver's review of Monsters vs. Aliens today, I came across the screen capture below. I still haven't seen the movie (it's in the queue and I'm looking forward to it!), but even during the trailers, the design of the humans bothered me. I liked the creature designs quite a bit, but the people looked weird. The guys' faces were oddly lumpy, and the women looked too similar to each other and to other CG designs I've seen. This particular screenshot, though, is particularly unflattering. It looks as though a 3D model was made based on a 2D drawing that didn't quite translate into an appealing puppet when viewed at all angles.
I think the eyes are the worst part, but the mouths and jawlines are funky too. Look at the mouth of the woman on the far left. With the way that the teeth are visible it just looks incorrect. Like I drew it, not understanding bone structure and anatomy well enough to bluff it. I know they're stylized, but it seems like you'd want to make sure the stylization didn't hurt the aesthetic functionality of the model before you approved the design.
I've noticed this with other CG films, but this screenshot really brought the issue into focus. Anyhow, still looking forward to the movie. I've heard it's a hoot and a half.